BMC
Abstract
Many toxicological test methods, including assays of cell viability and function, require an
evaluation of concentration-response data. This often involves curve fitting, and the resulting
mathematical functions are then used to determine the concentration at which a certain deviation
from the control value occurs (e.g. a decrease of cell viability by 15%). Such a threshold is called
the benchmark response (BMR). For a toxicological test, it is often of interest to determine the
concentration of test compound at which a pre-defined BMR of e.g. 10, 25 or 50% is reached. The
concentration at which the modelled curve crosses the BMR is called the benchmark concentration
(BMC). We present a user-friendly, web-based tool (BMCeasy), designed for operators without programming
skills and profound statistical background, to determine BMCs and their confidence intervals.
BMCeasy allows simultaneous analysis of viability plus a functional test endpoint, and it yields
absolute BMCs with confidence intervals for any BMR. Besides an explanation of the algorithm underlying
BMCeasy, this article also gives multiple examples of data outputs. BMCeasy was used within the EU-ToxRisk
project for preparing data packages that were submitted to regulatory authorities, demonstrating the
real-life applicability of the tool.
Read the manual
Open/Download an example file. - Microsoft Exel format
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